Are you looking to get involved with Aingeal? Simply get in touch through the form below and a team member will get back to you.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Developing a Novel Treatment for a Novel Target
Traditional depression treatments don't work for everyone- it's time to go back to the drawing board to reexamine the problem. Let's evaluate and integrate what we know about the neurobiology of depression to fix your brain.
Things that benefit brain health
Let's start by thinking about what goes on in your brain. Your neurons, or brain cells, make up a network of circuits that hosts the software of your mind. It's very much like a computer.
Healthy software relies on healthy hardware. How can we fix our brain hardware? Let's think about the things shown to benefit brain health:
High intensity exercise
Positive social enrichment
the Root cause
What's the mechanism behind these brain-boosters?
Brain-derived neurotrophic factor (BDNF) is a protein in your brain that helps to keep your neurons alive and healthy. These brain-boosters have been shown to increase BDNF activity.
Increase BDNF activity
Greater survival, protection, and connectivity of neurons
Aingeal is developing a novel class of therapeutic agents that increase the activity of BDNF to to strengthen synaptic connections to fix your neuronal "hardware."
Ketamine isn't perfect. Despite its therapeutic value, it carries risks of abuse, dissociation, and cognitive interference. Thus, our mission is to develop a treatment that safely and rapidly increase BDNF action to alleviate depression.
Recently, ketamine was approved for depression that resists conventional treatment. Ketamine is an NMDA receptor blocker that boosts BDNF activity and produces rapid antidepressant effects.